Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis

Completed

• Conditions: Sepsis; Immunosuppression

• Registration Number: NCT01976884
• Lead Sponsor: Changhai Hospital

Brief Summary

Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Status Verified: 2013-10
• Study First Submitted: 2013-10-30
• Study First Submitted QC: 2013-10-30
• Last Update Submitted: 2013-10-30
• Study First Posted: 2013-11-06
• Last Update Posted: 2013-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

• patients with severe sepsis
• patients with sepsis after PCNL for infectious kidney stone
• patients with pancreatic cancer
• healthy volunteers

Exclusion Criteria

• patients with immunodeficient diseases
• patients who accept glucocorticoid or immunosuppressant
• patients with an age older than 18 years
• patients providing the informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PD-L1 level on neutrophils	within 24h after recruitment	PD-L1 level on neutrophils was compared between different populations.

Secondary Outcome Measures

Name	Time	Method
28-day mortality	28 days after diagnosis of sepsis