Advanced imaging in HIPEC for peritoneal carcinomatosis of colorectal origin; a feasibility study
Completed
- Conditions
- Peritoneal CarcinomatosisPeritoneal Metastases100346521002747610017998
- Registration Number
- NL-OMON44157
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
-Oral and written informed consent
-Age 18 years and older
-Elective cytoreductive surgery followed by HIPEC
-Regular preoperative work-up
-Laparoscopic or open approach
Exclusion Criteria
-ASA score higher than 3
-Patients who have had prior major open abdominal surgery
-Contraindicattions for ICG, 5-ALA or ICB
-Medication that interacts with ICG, 5-ALA or ICB
-Chronic kidney failure (eGFR < 55)
-Chronic liver failure (ASAT, ALAT, AF or yGT > 2 times normal value)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To evaluate the sensitivity of Narrow Band Imaging, Three-dimensional imaging,<br /><br>Near-infrared Indocyanin Green Imaging, 5-ALA fluorescent imaging and Indigo<br /><br>Carmine Blue Spray Dye Chromoendoscopy in the detection of malignant lesions.<br /><br><br /><br>To evaluate if more malignant lesions are found with NBI, 3D, NIR-ICG, 5-ALA<br /><br>and SDCE, compared to conventional white light laparoscopy.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Operating time<br /><br>Blood loss<br /><br>Peritoneal carcinomatosis index (PCI) score<br /><br>(Serious) adverse events<br /><br>Patient characteristics<br /><br>Tumour characteristics</p><br>