Interhemispheric Connectivity and Compensation
- Conditions
- HealthyPeripheral Nerve Injury Upper Limb
- Interventions
- Other: STEGA-MRI
- Registration Number
- NCT05207878
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.
- Detailed Description
This is a one-visit study, in which right-handed participants (individuals with unilateral peripheral nerve injury to the right upper limb, and healthy controls) will complete surveys and perform movement tasks. Movement tasks will be performed inside and outside a magnetic resonance imaging (MRI) scanner.
Some participants will also receive transcranial magnetic stimulation (TMS) to briefly interfere with these putative brain networks.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 147
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Movement task STEGA-MRI All participants perform the STEGA-MRI (standardized tracing evaluation \& grapheme assessment - MRI) precision drawing task during fMRI scanning. Motor assessments outside the MRI do not qualify as interventions.
- Primary Outcome Measures
Name Time Method BOLD (blood oxygen level dependent) signal in ROIs (regions of interest) Day 1 BOLD signal in key ROIs (primary motor and posterior parietal cortex). ROI selection may be revisited after preliminary data review (35 participants)
- Secondary Outcome Measures
Name Time Method Drawing smoothness Day 1 Velocity smoothness in STEGA-MRI (Standardized Tracing Evaluation and Grapheme Assessment - MRI version) task
Hand choice Day 1 Percentage of grasps made with right hand
Trial Locations
- Locations (1)
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States