Interhemispheric Connectivity and Compensation

Not Applicable

Recruiting

• Conditions: Healthy; Peripheral Nerve Injury Upper Limb

• Registration Number: NCT05207878
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.

Detailed Description

This is a one-visit study, in which right-handed participants (individuals with unilateral peripheral nerve injury to the right upper limb, and healthy controls) will complete surveys and perform movement tasks. Movement tasks will be performed inside and outside a magnetic resonance imaging (MRI) scanner.

Some participants will also receive transcranial magnetic stimulation (TMS) to briefly interfere with these putative brain networks.

Study Timeline

• Study Start: 2021-12-09
• Study First Submitted: 2021-12-25
• Study First Submitted QC: 2022-01-11
• Study First Posted: 2022-01-26
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-15
• Last Update Posted: 2025-07-16
• Primary Completion: 2025-08-01
• Study Completion: 2025-08-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
BOLD (blood oxygen level dependent) signal in ROIs (regions of interest)	Day 1	BOLD signal in key ROIs (primary motor and posterior parietal cortex). ROI selection may be revisited after preliminary data review (35 participants)

Secondary Outcome Measures

Name	Time	Method
Drawing smoothness	Day 1	Velocity smoothness in STEGA-MRI (Standardized Tracing Evaluation and Grapheme Assessment - MRI version) task
Hand choice	Day 1	Percentage of grasps made with right hand

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States