Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery
Phase 4
Completed
- Conditions
- Morphine
- Interventions
- Drug: normal salineDrug: 1 mg morphine soak in epidural oxidized cellulose
- Registration Number
- NCT02067338
- Lead Sponsor
- Mahidol University
- Brief Summary
The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
Inclusion Criteria
- Age > 18 Yrs
- Good orientation and communication
Exclusion Criteria
- opioids or sulfonamides allergy
- Contraindication for use
- Epidural morphine
- Selective COX 2 inhibitor
- Patient-controlled analgesia (PCA)
- ASA class > 3
- BMI ≥ 35 kg/sq.m.
- Preoperative use of opioids within 6 Wks
- Intraoperative bleeding > 1000ml
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description normal saline normal saline During posterior lumbar spinal surgery,one group of patient received normal saline soaked collagen sponge. 1 mg morphine soak in epidural oxidized cellulose 1 mg morphine soak in epidural oxidized cellulose During posterior lumbar spinal surgery ,Another group of patients received 1 mg morphine-soaked in epidural oxidized cellulose.
- Primary Outcome Measures
Name Time Method VAS measurement was recorded at twenty-four hour after posterior lumbar spinal surgery then compare VAS between low-dose 1 mg morphine-soaked microfibrillar collagen sponge method with normal saline soked 2 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Siriraj hospital
🇹🇭Bangkoknoi, Bangkok, Thailand