The effect of nutritional supplementation on retinal functio

Not Applicable

Completed

• Conditions: Age-related macular disease; Eye Diseases; Other retinal disorders

• Registration Number: ISRCTN17842302
• Lead Sponsor: Bausch and Lomb (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10-01
• Last Update Posted: 8 May 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

All participants (both males and females) must be aged 18 - 80 years.

1. For early age-related maculopathy (ARM) group in either eye or both eyes:
1.1. Drusen
1.2. Drusen with hyperpigmentation
1.3. Drusen with hypopigmentation
2. For early age-related maculopathy (ARM) group and normal group in either eye or both eyes:
2.1. Best corrected visual acuity of 6/9 or better
2.2. Good central fixation (necessary for the multifocal electroretinogram [mfERG])
2.3. Clear optical media
2.4. No signs of other retinal or optic nerve disease
2.5. Good general health
2.6. No medication that affects the retina

Exclusion Criteria

1. Moderate to dense lens opacities
2. Intraocular lens
3. Corneal opacities
4. Glaucoma or ocular hypertension
5. Previous history of intraocular inflammation (e.g. uveitis)
6. Previous history of retinal detachment
7. Retinal disease
8. Previous retinal laser
9. Diabetes
10. Systemic hypertension
11. History of ocular trauma
12. Neurological disease
13. Advanced age-related macular disease (choroidal neovascularisation [CNV] or geographic atrophy [GA]) in the studied eye
14. Drugs causing retinal toxicity (chloroquine, cisplatin, oxazepam, vigabatrin)
15. Previous ocular surgery (excluding laser-assisted in situ keratomileusis [LASIK]/endothelial keratoplasty [EK])
16. Epilepsy

Study & Design

• Study Type: Interventional
• Study Design: Not specified