This is a study meant to observe the effect of two drugs, magnesium sulfate and dexmeditomidine, in reducing the requirement of other drugs used in general anesthesia.
Phase 1
- Conditions
- Health Condition 1: K819- Cholecystitis, unspecified
- Registration Number
- CTRI/2019/04/018757
- Lead Sponsor
- Jubilee Mission Medical College and Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. American society of anesthesiologists(ASA) physical status I and II
2. Scheduled for elective laparoscopic cholecystectomy(maximum duration 2hrs).
Exclusion Criteria
1. Hepatic, renal,respiratory disorders.
2. Seizure disorder,endocrinal,hematological disorders.
3. Obesity(BMI >30)
4. Prior neuromuscular disease
5. Any degree of heart block
6. Chronic use of opioids
7. Pregnancy
8. Prior treatment with calcium channel blockers and betablockers.
9. Patients receiving magnesium supplementation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Requirement of anesthetic agents: <br/ ><br> <br/ ><br>Timepoint: Requirement of anesthetic agents: <br/ ><br>1. Propofol induction dose <br/ ><br>2. Propofol maintenance dose(every 30 mins) <br/ ><br>3. Fentanyl maintenance dose <br/ ><br>4. Atracurium maintenance dose <br/ ><br>
- Secondary Outcome Measures
Name Time Method Hemodynamic stability: <br/ ><br>1. Heart rate <br/ ><br>2. Blood pressure <br/ ><br>3. Mean arterial pressure(MAP)Timepoint: 1. Preoperative <br/ ><br>2. After study drug <br/ ><br>3. After induction <br/ ><br>4. After intubation <br/ ><br>5. Intraoperative at 10 mins interval <br/ ><br>6. After surgery <br/ ><br>7. After extubation;Recovery indices: <br/ ><br>1. Recovery time <br/ ><br>2. Orientation time <br/ ><br>3. Extubation time.Timepoint: 1. Time elapsed between stoppage of propofol infusion and a qCON value of 80 is Recovery time. <br/ ><br>2. Time elapsed between stoppage of propofol infusion and response to verbal commands is Orientation time. <br/ ><br>3. Time elapsed between stoppage of propofol infusion and extubation is extubation time.