Identification of Biomarkers in Extracellular Vesicles Associated With Marrow Adiposity and Bone Deterioration Caused by Nutritional Deficiencies

Maimónides Biomedical Research Institute of Córdoba1 site in 1 country30 target enrollmentMay 15, 2025

ConditionsAnorexia Nervosa Restricting Type Anorexia Nervosa (DSM-IV Revised Criteria)

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Anorexia Nervosa Restricting Type
Sponsor: Maimónides Biomedical Research Institute of Córdoba
Enrollment: 30
Locations: 1
Primary Endpoint: Biomarkers related to medullary adiposity
Status: Not yet recruiting
Last Updated: 12 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa. The main question it aims to answer is:

Can this medullary adiposity be associated with the bone deterioration observed in this population?

Participants will be assessed for body composition and a blood sample will be taken by non-invasive techniques.

Registry

clinicaltrials.gov

Start Date

May 15, 2025

End Date

July 31, 2026

Last Updated

12 months ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Maimónides Biomedical Research Institute of Córdoba

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•For AN group:
•Diagnosis of active AN according to DSM-5 criteria
•BMI of less than 17kg/m2
•Present amenorrhoea in the 3 months prior to the start of the study.
•For AN-R group:
•Achieved weight gain of more than 85%.
•Normal menstruation in the last 3 months.
•For Control group:
•Population of the same age and gender as the AN and AN-R groups.
•If pubertal population, presenting a chronological age of ± 2 years.

Exclusion Criteria

•Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study.
•Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function.
•Do not take calcium or vitamin supplements.