Extracellular Vesicles as Biomarkers for Chronic Renal Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 143
- 试验地点
- 2
- 主要终点
- variation of urinary extracellular vesicle concentration between both groups
研究概览
简要总结
The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subject > 18 years old
- •healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
- •CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²
排除标准
- •patients under dialysis protocols
- •renal transplant patients
结局指标
主要结局
variation of urinary extracellular vesicle concentration between both groups
时间窗: one day
variation of urinary extracellular vesicle concentration between both groups : healthy and CRF patients Urinary extracellular vesicle concentrations will be measured as number of extracellular vesicles per mL of urine
次要结局
未报告次要终点