Extracellular Vesicles as Biomarkers for Chronic Renal Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Renal Failure
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Enrollment
- 143
- Locations
- 1
- Primary Endpoint
- variation of urinary extracellular vesicle concentration between both groups
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.
Investigators
Eligibility Criteria
Inclusion Criteria
- •subject \> 18 years old
- •healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
- •CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²
Exclusion Criteria
- •patients under dialysis protocols
- •renal transplant patients
Outcomes
Primary Outcomes
variation of urinary extracellular vesicle concentration between both groups
Time Frame: one day
variation of urinary extracellular vesicle concentration between both groups : healthy and CRF patients Urinary extracellular vesicle concentrations will be measured as number of extracellular vesicles per mL of urine