Influence of perinterventional acupuncture on the incidence of postoperative delirium after elective, endoprosthetic replacement of the hip joint

Not Applicable

• Conditions: F05; Delirium, not induced by alcohol and other psychoactive substances

• Registration Number: DRKS00013158
• Lead Sponsor: niversitätsklinikum Knappschaftskrankenhaus Bochum, Universitätsklinikum der Ruhr-Universität Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

Patients scheduled for total endoprothetic hip Joint replacement were included

Exclusion Criteria

o Age <65 years
o Pre-existing dementia
o immunosuppression
o Chronic skin diseases
o Rejection by patients
o Previous participation in this study
o Drugaddicted patients , psychosis
o Patients with heart pacemaker and deep brain stimulation
o Existing anticholinergic medication

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of postoperative delirium after total hip joint replacement<br><br>Preoperative, when transferred from the recovery room and 24 h and 48 h postoperatively, the Delire estimation is performed according to the Confusion Assessment Method for intensive care units (CAM-ICU)

Secondary Outcome Measures

Name	Time	Method
o Activity of acetylcholineestrase (ACHE) and butyrylcholinesterase (BCHE) in the blood<br>o Determination TNFa, NSE, S-100 ß protein<br>o Epigenetic markers such as DNA methylation, acetylation, and histone modifications<br>o Hospital lenght of stay<br><br>These analyses are made at 4 times (during premedication, directly postoperatively, first and second postoperative day) with 15 ml of venous whole blood.