An experimental study comparing the effects of treatment response and severity of difficulty in swallowing in patients with pharynx or larynx cancer treated with two different radiation techniques (D0-IMRT versus standard IMRT).
Phase 2
- Conditions
- Health Condition 1: C00-D49- Neoplasms
- Registration Number
- CTRI/2021/08/036041
- Lead Sponsor
- Karthik Subramaniam Thiagarajan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Patients with stage T2-T4, N+, M0 carcinoma of oropharynx, hypopharynx or larynx with squamous cell carcinoma histology only
2) ECOG performance 0-2
3) Written informed consent.
Exclusion Criteria
• Patients with head and neck cancer with non-squamous cell carcinoma histology
• Cancer sites other than oropharynx, hypopharynx, or supraglottic larynx
• Patients with T1 N0 M0 (or M1) disease in the above-mentioned sites
• Patients with recurrent cancer in the above-mentioned sites
• Patients not fit for concurrent chemoradiation (or receiving chemotherapy other than weekly cisplatin)
• Documented evidence of pre-existing swallowing dysfunction (not related to cancer)
• Previous radiotherapy to the head and neck region
• ECOG performance 3-4
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method