Dysphagia releif in advanced esophageal cancer through Radiotherapy

Not Applicable

• Conditions: Health Condition 1: C159- Malignant neoplasm of esophagus, unspecified

• Registration Number: CTRI/2023/05/052661
• Lead Sponsor: A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Endoscopic and biopsy-proven carcinoma of the esophagus either adenocarcinoma or squamous cell carcinoma

Patient not suitable for radical treatment either

Due to poor KPS

Extent of local disease (Primary Stage T4b)

Unsuitable for concurrent chemotherapy

Metastatic disease at presentation

Lesions of the thoracic esophagus and the abdominal esophagus that do not involve the cardiac of the stomach

Recent imaging (a computed tomography (CT) of the chest and abdomen or whole body PETCT) not more than 3 months old

Maximum tumor length not more than 10 cm

Dysphagia immediately before radiation

Karnofskys performance score is between 40 and 90 inclusive and at baseline

Signed informed consent

Exclusion Criteria

Age less than 18

Expected intraluminal catheter insertion not possible even after conditioning radiotherapy

Tracheoesophageal fistula or deep mucosal ulceration

Perforation or massive esophageal bleeding

Stents in situ (i.e. not removed before the first HDR ILBT)

Previous thoracic radiation therapy for any cause either EBRT or ILBT

Evidence of other uncontrolled malignancies or evidence of synchronous head and neck or lung primary cancers (regardless of whether those malignancies could be managed with curative intent)

Pregnant or lactating patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified