Effect of diltiazem and fluoxetine on DES
Phase 3
Recruiting
- Conditions
- Distal esophageal spasm.Dyskinesia of esophagusK22.4
- Registration Number
- IRCT20220413054528N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Age more than 18 years
All patients diagnosed as distal esophageal manometry according to manometry
Exclusion Criteria
1.Patients abusing drugs
2.Patients with systemic disorders including :Mastocytosis Systemic vasculitis, Sarcoidosis, Hypothyroidism, Diabetes mellitus, Fibromyalgia, Adrenal insufficiency, Coeliac disease, inflammatory bowel disease, Hypertension (high blood pressure), Metabolic syndrome, AIDS, Graves' disease, Systemic lupus erythematosus, Rheumatoid arthritis, Atherosclerosis, Sickle cell disease, Myasthenia gravis, Systemic Sclerosis, Sinusitis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of clinical manifestations (chest pain, dysphagia). Timepoint: Before intervention and 2 months after intervention. Method of measurement: Questionnaire of patients symptoms, Questionnaire of quality of life, Eckardt score, Psychological questionnaire HADS and SF-36, esophageal manometry.
- Secondary Outcome Measures
Name Time Method Improvement of esophageal manometric parameters. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Esophageal manometry.