Wheezing Illnesses Study Leidsche Rijn/ Adolescents

Recruiting

Conditions: mentaal welzijn en veerkracht
asthma and well-being of children in puberty
10024967
10047066

Registration Number: NL-OMON54512

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 1000

Inclusion Criteria

Children who reached the age of 12-18 years and who already participated in the
WHISTLER-0 and/or WHISTLER/Cardio and/or WHISTLER/Cardio2 study, and who's
parents and child are willing to give informed consent to participate in this
study. From age 16, informed consent will be obtained from the adolescent only.
Children and adolescents aged 12-18 years who already participated in the
WHISTLER round aged 12-16 years consisting of only online questionnaires,
because of the corona epidemic, will be included. This group, which consists of
around 300 children, will be approached for this new WHISTLER/ Adolescent round
since it consists of new physical measurements and an amended online
questionnaire.

Exclusion Criteria

There are no exclusion criteria.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Part 1: cIMT and PWV as cardiovascular outcomes.<br /><br>Part 2: lung function measurements (spirometry).<br /><br>Part 3: QoL, happiness, well-being and resilience will be measured using<br /><br>validated questionnaires.<br /><br>Part 4: different markers of disease activity defined through questionnaires,<br /><br>physical examination and markers in the blood, depending on the chronic<br /><br>disorder, will be examined in the WHISTLER population. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Part 1: Carotid artery distension using ultrasound. Endothelial functioning<br /><br>using PAT. Dyslipidemia using a lipid panel including total cholesterol, total<br /><br>triglycerides, apolipoprotein B (ApoB), lipoprotein a (Lp(a)), HDL- and<br /><br>LDL-cholesterol and HbA1c. Inflammation using CRP levels. Intra-abdominal and<br /><br>subcutaneous fat measured by ultrasound.<br /><br>Part 2: Allergic sensitization patterns and specific IgE-profiling in the blood<br /><br>next to reported allergies by a questionnaire.</p><br>