WHeezing Illnesses Study Leidsche Rijn / Childhood adiposity and Arterial Disease Onset 2

Completed

Conditions: cardiovasculaire aandoeningen en overgewicht
Cardiovascular diseases and overweight

Registration Number: NL-OMON43961

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 1000

Inclusion Criteria

children who reached the age of 8 years and who already participated to the WHISTLER and WHISTLER/Cardio study, and who's parents are willing to give informed consent to participate to this study.

Exclusion Criteria

There are no exclusion criteria. In case of current or recent (last week) infections, the second visit to obtain the blood sample will be rescheduled. (this is not applicable after may 2012, as the venipuncture has stopped).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To study the association between fat distribution and the adipokine profile in<br /><br>childhood, the main study parameters consist of anthropometric parameters,<br /><br>namely weight, quetelet index, waist circumference, and the main outcome<br /><br>parameters are the adipokine concentrations and clusters of adipocytokines.<br /><br>Moreover, to determine the effect of adipocytokines on the vascular system, the<br /><br>adipokine profile is used as determinant and the main outcome parameters are<br /><br>the carotid IMT and vascular stiffness.<br /><br>In the second part of the study the main study parameters are changes in fat<br /><br>distribution between the age of 5 and 8 years. The main outcome parameters are<br /><br>the changes in Z-score IMT and distension at the age of 8 years.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Since the abdominal fat will be measured ultrasonographically as well,<br /><br>secondary study parameters will be the intra-abdominal fat and subcutaneous fat<br /><br>as determinants of adipokine concentration and of IMT and vascular stiffness. </p><br>