Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Stool frequency
研究概览
简要总结
The current study was carried out to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii among the local pediatric population presenting with acute watery diarrhea.
详细描述
The results and importance of effective treatment for acute watery diarrhea in pediatric patients vary throughout the world. Previously, very limited literature was available comparing the efficacy of Bacillus clausii and Saccharomyces boulardii in acute watery diarrhea, providing mixed results. The current study aims to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 3 Months 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of either gender
- •Aged 3 months to 5 years
- •With acute watery diarrhea last less fewer than 14 days
- •Presenting with mild to moderate dehydration
排除标准
- •Patients with a history of blood or pus in their stools
- •History of recent antibiotic or probiotic treatment
- •Patients with immunodeficiency conditions, acute systemic illnesses, or chronic diarrhea
- •Patients with hypersensitivity to Bacillus clausii or Saccharomyces boulardii
研究组 & 干预措施
Saccharomyces boulardii +zinc+ ORS group
Patients were given zinc with ORS and Saccharomyces boulardii
干预措施: ORS (Drug)
Bacillus clausii + zinc+ ORS group
Patients received zinc supplementation with ORS and Bacillus clausii
干预措施: Bacillus clausii (Drug)
Bacillus clausii + zinc+ ORS group
Patients received zinc supplementation with ORS and Bacillus clausii
干预措施: Zinc (Drug)
Bacillus clausii + zinc+ ORS group
Patients received zinc supplementation with ORS and Bacillus clausii
干预措施: ORS (Drug)
Saccharomyces boulardii +zinc+ ORS group
Patients were given zinc with ORS and Saccharomyces boulardii
干预措施: Saccharomyces boulardii (Drug)
Saccharomyces boulardii +zinc+ ORS group
Patients were given zinc with ORS and Saccharomyces boulardii
干预措施: Zinc (Drug)
结局指标
主要结局
Stool frequency
时间窗: 5 days
Number of stools per day
Stool consistency
时间窗: 5 days
Graded on a five-point scale as firm, soft, thick liquid, opaque watery, and watery
次要结局
未报告次要终点