跳至主要内容
临床试验/NCT01863212
NCT01863212Unknown不适用

Investigating the Role of the FTO Gene in Reward System Activation During Visual Presentation of Food Images With fMRI Technique

Uppsala University3 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2010年9月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
500
试验地点
3
主要终点
Genotyping for variants in the FTO gene associated with overweight and obesity

研究概览

简要总结

In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 37 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • No medications (except contraceptives including estrogen)
  • No metabolic disorders/diseases
  • Right handed
  • Color vision
  • Normal sleep-wake rhythm (eg. shift workers can not participate)

排除标准

  • Specific preferences of food, for example vegetarians
  • Grandparents originating from country outside the Nordic area
  • Metallic implants

结局指标

主要结局

Genotyping for variants in the FTO gene associated with overweight and obesity

时间窗: Blood sampling for genetic analyse is performed at the initiation visit

次要结局

未报告次要终点

研究者

发起方
Uppsala University
申办方类型
Other
责任方
Sponsor

研究点 (3)

Loading locations...

相似试验