Investigating the Role of the FTO Gene in Reward System Activation During Visual Presentation of Food Images With fMRI Technique
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 500
- 试验地点
- 3
- 主要终点
- Genotyping for variants in the FTO gene associated with overweight and obesity
研究概览
简要总结
In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 37 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No medications (except contraceptives including estrogen)
- •No metabolic disorders/diseases
- •Right handed
- •Color vision
- •Normal sleep-wake rhythm (eg. shift workers can not participate)
排除标准
- •Specific preferences of food, for example vegetarians
- •Grandparents originating from country outside the Nordic area
- •Metallic implants
结局指标
主要结局
Genotyping for variants in the FTO gene associated with overweight and obesity
时间窗: Blood sampling for genetic analyse is performed at the initiation visit
次要结局
未报告次要终点
