Ultrafiltration on Coagulation Function in Cardiac Surgery
Not Applicable
Recruiting
- Conditions
- Cardiac Valve Disease
- Interventions
- Procedure: Ultrafiltration
- Registration Number
- NCT04031144
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
To determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (CPB), on coagulation profile in patients undergoing cardiac surgery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB)
- maximal clot formation (MCF) in ROTEM-EXTEM is reduced
Exclusion Criteria
- MCF > 50.5 mm before applying ultrafiltration
- transfusion of packed RBC> 3 units during CPB
- total ultrafiltration volume < 250 ml
- hyperfibrinolysis (lysis% > 10%) before applying ultrafiltration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Ultrafiltration Ultrafiltration Ultrafiltration is applied at the end of cardiopulmonary bypass. Maximal clot formation (MCF) of ROTEM-EXTEM tracing is reduced before applying the ultrafiltration.
- Primary Outcome Measures
Name Time Method Change of Maximal clot formation (MCF) in rotational thromboelastometry, EXTEM assay 5 min-before and 5 min-after applying ultrafiltration change of MCF in EXTEM assay before and after applying ultrafiltration
- Secondary Outcome Measures
Name Time Method Change of Clotting time (CT) in rotational thromboelastometry, EXTEM assay 5 min-before and 5 min-after applying ultrafiltration change of CT in EXTEM assay before and after applying ultrafiltration
Change of Percent of lysis (lysis%) in rotational thromboelastometry, EXTEM assay 5 min-before and 5 min-after applying ultrafiltration change of lysis% before and after applying ultrafiltration
Hematocrit (Hct) change 5 min-before and 5 min-after applying ultrafiltration change of Hct before and after applying ultrafiltration
Change of Maximal clot formation at 5 min (A5) in rotational thromboelastometry, FIBTEM assay 5 min-before and 5 min-after applying ultrafiltration change of A5 in FIBTEM assay before and after applying ultrafiltration
Trial Locations
- Locations (1)
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of