NCT04031144已完成不适用
Effect of Ultrafiltration Before Weaning From Cardiopulmonary Bypass on Post-bypass Coagulation Function in Cardiac Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Change of Maximal clot formation (MCF) in rotational thromboelastometry, EXTEM assay
研究概览
简要总结
To determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (CPB), on coagulation profile in patients undergoing cardiac surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Months 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB)
- •maximal clot formation (MCF) in ROTEM-EXTEM is reduced (< 50.5 mm before applying ultrafiltration)
排除标准
- •transfusion of packed RBC> 3 units during CPB
- •total ultrafiltration volume < 250 ml
- •hyperfibrinolysis (lysis% > 10%) before applying ultrafiltration
结局指标
主要结局
Change of Maximal clot formation (MCF) in rotational thromboelastometry, EXTEM assay
时间窗: 5 min-before and 5 min-after applying ultrafiltration
change of MCF in EXTEM assay before and after applying ultrafiltration
次要结局
- Change of Clotting time (CT) in rotational thromboelastometry, EXTEM assay(5 min-before and 5 min-after applying ultrafiltration)
- Change of Percent of lysis (lysis%) in rotational thromboelastometry, EXTEM assay(5 min-before and 5 min-after applying ultrafiltration)
- Hematocrit (Hct) change(5 min-before and 5 min-after applying ultrafiltration)
- Change of Maximal clot formation at 5 min (A5) in rotational thromboelastometry, FIBTEM assay(5 min-before and 5 min-after applying ultrafiltration)
研究者
Tae-Yop Kim, MD PhD
Professor of Anesthesiology
Konkuk University Medical Center
研究点 (1)
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