Modified Ultrafiltration in Cardiac Surgery
- Conditions
- Transfusion RequirementsCoagulopathyRethoracotomyBlood Loss
- Registration Number
- NCT00998647
- Lead Sponsor
- Goethe University
- Brief Summary
The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.
- Detailed Description
The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- patients undergoing complex cardiac surgery procedures
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ex vivo platelet aggregation (TRAPtest) 20 min after filtration
- Secondary Outcome Measures
Name Time Method secondary hemostasis assessed by ROTEM 20 min before and after filtration blood loss 24 h after filtration kind and number of transfused blood products 24h after filtration conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration) 20 min before and after filtration rate of rethoracotomy for bleeding 24h after filtration
Trial Locations
- Locations (1)
Goethe University hospital, Clinic for Anaesthesioloy
🇩🇪Frankfurt am Main, Germany
Goethe University hospital, Clinic for Anaesthesioloy🇩🇪Frankfurt am Main, Germany