a research done to see if muscle girth of thigh measured using ultrasound can be linked with a nutritional component in very sick icu patients

Conditions: Other specified symptoms and signsinvolving the circulatory and respiratory systems,

Registration Number: CTRI/2022/03/041092

Lead Sponsor: Nizwa Hospital

Brief Summary: Patients coming under severe sepsis criteria will be considered for the study- those admitted to MDICU since day 1, their calorie:n2 ratio obtained from the nutritional registry maintained in our hospital is calculated daily and at the same time quadriceps muscle girth of the patient is measured using USG method, where rectus femoris, vastus intermidius muscle is visualized from a linear probe of 8-12 MHz kept at anterior 2/3rd and 1/3 of the thigh measuring from the anterior superior iliac spine and the superior margin of the patella and patient maintained in supine position with both legs kept in a neutral position

we have a standardized protocol for measuring muscle girth- unfortunately, pictures cant be posted here as soft ware not supported to paste.

The cumulative mean of calorie:n2 ratio is taken and compared with muscle girth cumulative mean to ascertain if there is any statistical correlation

as per our hypothesis, we believe there is a correlation between the two parameters

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Applicable

Sex: All

Target Recruitment: 30

Inclusion Criteria

1 All patients admitted to multi disciplinary ICU with severe sepsis as defined by sepsis 3 guidelines 2 Age group â€“ 18 yrs to 60 yrs.

Exclusion Criteria

1 Obese patients â€“ whose BMI > 30 2 Muscle disorders- including myositis/rhabdomyolysis 3 Patients with disuse atrophy of muscles â€“ eg- stroke/quadriplegics/paraplegics 4 Burns patients 5 Pregnant patients 6 Patients on total parentral nutrition 7 Patients in whom enteral nutrition is contraindicated 8 Malabsorption syndrome 9 Patients who are not willing for the study.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To look for any statistical correlation between the cumulative mean of the calorie:n2 ratio with that of quadriceps muscle thickness	1 year

Secondary Outcome Measures

Name	Time	Method
To be able to establish the time duration for any change in muscle thickness in severe sepsis patients â€“ USG guided demonstrable change	1 year

Trial Locations

Locations (1): Nizwa Hospital
🇮🇳
Adult, ICU, India
Nizwa Hospital
🇮🇳Adult, ICU, India
Mayur Ramakrishna
Principal investigator
968-71139687
mayur.chillal31@gmail.com