Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients Undergoing Cesarean Section: a Randomized Double Blinded Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Norepinephrine
- Conditions
- Hypotension
- Sponsor
- Air Force Military Medical University, China
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- incidence of hypotension
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Incidence of hypotension is high in parturients after spinal anesthesia. Ephedrine could be used to treat hypotension but lead to lower fetal pH as well. This study is to compare the effects of norepinephrine and ephedrine on hypotension in parturients.
Detailed Description
Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. Ephedrine could be used to treat hypotension but lead to lower fetal pH, which may be related to worse fetal outcome.Norepinephrine could improve the hypotension to the same extent as phenylephrine. In this study, we tend to compare the effects of norepinephrine and ephedrine on hypotension in parturients and on fetal acid status.
Investigators
Zhihong LU
Dr
Air Force Military Medical University, China
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for elective cesarean section
Exclusion Criteria
- •Patients with severe pre-eclampsia
- •Patients with contraindications for spinal anesthesia
- •Patients with multiple pregnancy
- •Patients with gestation \<38w
Arms & Interventions
norepinephrine
norepinephrine is injected after spinal anesthesia
Intervention: Norepinephrine
ephedrine
ephedrine is injected after spinal anesthesia
Intervention: Ephedrine
Outcomes
Primary Outcomes
incidence of hypotension
Time Frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
Secondary Outcomes
- pH value of fetal arterial blood(just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery)
- lowest neonatal cerebral oxygen saturation(from clamp of the umbilical cord to 10 min later, 10min in total)
- lactate level of fetal arterial blood(just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery)
- number of rescue vasoactive agent(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- incidence of bradycardia(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- incidence of dizzy(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- fetal arterial partial pressure of oxygen(just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery)
- arterial base excess of fetal arterial blood(just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery)
- incidence of nausea and vomiting(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- incidence of chest congestion(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- incidence of dyspnea(from immediately after spinal anesthesia to 30min after spinal anesthesia)
- Apgar scores of the neonates(from clamp of umbilical cord to 5min after clamping)