Comparison of Intravenous Phenylephrine and Norepinephrine for Treatment of Spinal-induced Hypotension in Caesarian Deliveries
Overview
- Phase
- Phase 3
- Intervention
- Phenylephrine
- Conditions
- Spinal Induced-hypotension
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- compare percentage of incidence of bradycardia between the two groups
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Hypotension after spinal anaesthesia for cesarean deliveries is frequently encountered. Phenylephrine an α-agonist is commonly used for the prevention and treatment of spinal-induced hypotension. Phenylephrine causes baroreceptor-mediated bradycardia leading to subsequent reduction in cardiac output. Preservation of heart rate and cardiac output is important in high-risk conditions such as placental insufficiency, fetal distress and maternal cardiac disease. Recently, norepinephrine has been found as effective as phenylephrine in treatment of spinal induced hypotension. When norepinephrine is used as a bolus, it is effective at maintaining blood pressure while also conferring a greater heart rate and cardiac output compared to phenylephrine.
Investigators
ALLEN SUWAL
Resident Anaesthesiology
Tribhuvan University Teaching Hospital, Institute Of Medicine.
Eligibility Criteria
Inclusion Criteria
- •Elective cesarean delivery under spinal anaesthesia ASA PS II Age ≥18 years Singleton pregnancy beyond 37 weeks' gestation Weight between 50 and 100 kg Height between 150 and 180 cm
Exclusion Criteria
- •Patient refusal to participate Allergy or hypersensitivity to Norepinephrine or Phenylephrine Preexisting or pregnancy-induced hypertension Cardiovascular or cerebrovascular disease Fetal abnormalities Use of monoamine oxidase inhibitors or tricyclic antidepressants
Arms & Interventions
Phenylephrine group
Phenylephrine 100mcg was administered manually by the anaesthesiologist every time the SBP was 20% lower than baseline and the HR ≥60 bpm.
Intervention: Phenylephrine
Norepinephrine group
Norepinephrine 8mcg was administered manually by the anaesthesiologist every time the SBP was 20% lower than baseline and the HR ≥60 bpm.
Intervention: Norepinephrine
Outcomes
Primary Outcomes
compare percentage of incidence of bradycardia between the two groups
Time Frame: 6 months
To compare percentage of incidence of hypotension between two groups.
Time Frame: 6 months
To compare blood pressure between two groups.
Time Frame: 6 months