Long Term Physical Training in Asthma

Not Applicable

Completed

• Conditions: Asthma
• Interventions: Procedure: Exercise training

• Registration Number: NCT01097473
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

This controlled study is undertaken to investigate the effects of a long term outpatient training program on physical fitness and quality of life in elderly asthmatics.

Detailed Description

Physical training is well known to support a healthy lifestyle. Patients with asthma are often unnecessarily restricted of physical activities or avoid exercise due to the unpleasant experience of exercise-induced dyspnea. As a consequence both children and adults with asthma are less fit than their peers. Like in healthy individuals, regular training supports health in asthmatics. In short-term training programs improvements of physical capabilities have been achieved in children and young adults with asthma. Programs of longer durations than 3 months have not been published in controlled trials. Effects of exercise training on quality of life in adult asthmatics are lacking.

Study Timeline

• Study Start: 1996-04
• Primary Completion: 1998-01
• Study Completion: 1998-03
• Status Verified: 2010-03
• Study First Submitted: 2010-03-31
• Study First Submitted QC: 2010-03-31
• Last Update Submitted: 2010-03-31
• Study First Posted: 2010-04-01
• Last Update Posted: 2010-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• physician diagnosed asthma
• non-smoker
• stable condition
• informed consent

Exclusion Criteria

• participation in pulmonary rehabilitation in the past 12 months prior to study inclusion
• unability to attend training sessions on a regular basis for one year
• symptomatic coronary heart disease
• uncontrolled heart failure
• hemodynamically relevant cardiac rhythm disorders
• hemodynamically relevant cardiac valvular disorders
• uncontrolled arterial hypertension
• hypercapnic respiratory failure
• severe hypoxemia (i.e. PaO2 <50 mm Hg resp. SaO2 <80% at rest)
• history of decompensated right heart failure
• pulmonary arterial hypertension (PA mean pressure at rest >20 mm Hg)
• severe osteoporosis
• severe airway obstruction (FEV1 <50% predicted, FEV1 <60% predicted following bronchodilatation)
• maximum work rate of less than 50 watt during ergometer testing
• uncontrolled asthma
• COPD exacerbation
• severe adipositas (BMI >35 kg/m2)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise training	Exercise training	Subjects participate in a once weekly supervised exercise training group, duration of 60 min.

Primary Outcome Measures

Name	Time	Method
Maximum oxygen uptake	One year	Maximum oxygen uptake measured during unsteady state cycle ergometer test with work increments of 10 watts each minute until exhaustion.

Secondary Outcome Measures

Name	Time	Method
General quality of life	One year	Assessment of general quality of life using the german version of the SF-36 questionaire.
Disease-specific quality of life	One year	Assessment of the disease-specific quality of life using the Asthma Quality of Life Questionnaire (AQLQ)

Trial Locations

Locations (1)

University Medical Center Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany