Verapamil effect on refractory epilepsy treatment
- Conditions
- epilepsy.Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
- Registration Number
- IRCT2012121711778N1
- Lead Sponsor
- Shiraz University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
- Male/female patients, aged 18 and above.
- Diagnosis of epilepsy made on the basis of clinical and EEG findings.
- Refractory epilepsy is defined as failure of two or more AEDs at maximal tolerated doses and 2 or more seizures per month.
- There have been no more than 4 weeks between seizures over the 2 months prior to entry to the study.
- Having stable medication regimen for 8 weeks prior to entry.
- Patient is male or a non-pregnant female adequately protected from conception.
- Informed consent by patients or their families/care givers.
Exclusion criteria:
- Patient has a progressive neurological condition.
- Patient has a history of non-compliance for seizure diary completion or frequent clinic visits.
- Patient is pregnant at the time of enrolment.
- Patient has any serious medical illness or major psychiatric disorder, history of psudoseizure, or history of suicidal attempt in the past 5 years.
- Patient has any contraindication for verapamil administration including:
severe GI narrowing, heart failure, hypertrophic cardiomyopathy, cardiac conduction disturbances, hypotension, hepatic impairment, renal impairment, and known history of hypersensitivity to verapamil.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Seizure frequency. Timepoint: monthly. Method of measurement: questionnaire and check list.;Seizure quality. Timepoint: monthly. Method of measurement: questionnaire and check list.
- Secondary Outcome Measures
Name Time Method Blood pressure. Timepoint: one week after starting Verapamil, one week after titrating Verapamil, and then monthly. Method of measurement: Digital blood pressure monitor.;Pulse rate. Timepoint: one week after starting Verapamil, one week after titrating Verapamil, and then monthly. Method of measurement: counting manually.