Zevalin-beam for Aggressive Lymphoma

Phase 3

Completed

• Conditions: Non-Hodgkin's Lymphoma
• Interventions: Procedure: BEAM chemotherapy and autologous stem-cell transplantation; Drug: ibritumomab tiuxetan

• Registration Number: NCT00491491
• Lead Sponsor: Sheba Medical Center

Brief Summary

The study hypothesis is that the addition of zevalin radioimmunotherapy to the conditioning regimen given prior to BEAM high-dose chemotherapy and autologous stem cell transplantation in patients with aggressive lymphoma will reduced disease recurrence rate and improve overall and disease-free survival.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06
• Study First Submitted: 2007-06-25
• Study First Submitted QC: 2007-06-25
• Study First Posted: 2007-06-26
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Status Verified: 2020-08
• Results First Submitted: 2020-08-13
• Results First Submitted QC: 2020-08-13
• Last Update Submitted: 2020-08-13
• Results First Posted: 2020-08-31
• Last Update Posted: 2020-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patients with CD20 positive diffuse large B-cell lymphoma as confirmed by a pathological biopsy report.
2. Patients who are candidates for autologous stem-cell transplantation due to primary refractory or first relapse of disease.
3. Patients must have chemo-sensitive disease achieving at least partial response (Cheson 2007 criteria) to last chemotherapy.
4. Age ≥ 18 years and age ≤ 70
5. Patients with adequate autologous stem cell collection for transplantation (target ≥ 2.5 x 106 CD34+ cells/kg).
6. Patients must sign written informed consent.
7. Adequate birth control in fertile patients.
8. All prior chemotherapy completed at least three weeks before study treatment.
9. Marrow involvement less than 25% at transplantation, no limitation on blood counts (low platelet count allowed).
10. Negative HIV antibody.

Exclusion Criteria

1. 1. Chemo-refractory disease as determined by less than partial response (Cheson 2007 Criteria) to last chemotherapy.
2. Two or more relapses after initial response to induction chemotherapy.
3. High-grade transformation from earlier diagnosis of low-grade lymphoma. Patients with "De Novo" Transformed DLBCL, defined as DLBCL only on lymph node biopsy and a discordant marrow with para-trabecular small cells at first diagnosis of lymphoma, are eligible if adherent all other selection criteria.
4. Bilirubin > 3.0 mg/dl, transaminases > 3 times upper normal limit.
5. Creatinine > 2.0 mg/dl.
6. ECOG Performance status > 2.
7. Uncontrolled infection.
8. Pregnancy or lactation.
9. Abnormal lung diffusion capacity (DLCO < 40% predicted).
10. Severe cardiovascular disease; New York Heart Association (NYHA) Functional Classification ≥2.
11. Active CNS disease involvement.
12. Presence of any other malignancy or history of prior malignancy within 5 years of study entry. Within 5 years, patients treated for Stage I or II cancers are eligible provided they have a life expectancy > 5 years in relation to this prior malignance. The 5-year exclusion rule does not apply to-non melanoma skin tumors and in situ cervical cancer.
13. Pleural effusion or ascites > 1 liter.
14. Known hypersensitivity to rituximab.
15. Psychiatric conditions/disease that impair the ability to give informed consent or to adequately co-operate.
16. Prior radioimmunotherapy.
17. Prior autologous or allogeneic HSCT.
18. Active evidence of Hepatitis B or C infection; Hepatitis B surface antigen positive.
19. Patients who have had prior radiation to the lung will be excluded from the study, although mediastinal irradiation will be permitted if minimal lung is in the treatment volume.
20. Patients who have received >500cGy radiation to the kidneys will be excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
standard BEAM	BEAM chemotherapy and autologous stem-cell transplantation	standard BEAM chemotherapy
Z-BEAM	BEAM chemotherapy and autologous stem-cell transplantation	ibritumomab tiuxetan (zevalin) BEAM
Z-BEAM	ibritumomab tiuxetan	ibritumomab tiuxetan (zevalin) BEAM

Primary Outcome Measures

Name	Time	Method
Overall Survival	2 years after transplantation	actuarial 2 year survival

Secondary Outcome Measures

Name	Time	Method
Grade III Toxicity	100 days after transplantation	incidence of infection, grade III-IV toxicities, treatment-related mortality
Progression-free Survival	2 years after transplantation	actuarial 2-year PFS
Clinical Response	100 days after transplantation	complete response (CR) and partial response (PR) proportion at day 100,
Hematopoietic Recovery	100 days after transplantation	time to hematopoietic recovery
Secondary Malignancies	5 years after transplantation	incidence of myelodysplastic syndrome (MDS), and secondary acute myelogenous leukemia (AML).

Trial Locations

Locations (9)

Cedars Sinai Medical Center; 🇺🇸 Los Angeles, California, United States

Moffitt Cancer Center; 🇺🇸 Tampa, Florida, United States

Georg-August Universität; 🇩🇪 Göttingen, Germany

Northwestern University; 🇺🇸 Chicago, Illinois, United States

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States

Chaim Sheba Medical Center; 🇮🇱 Tel Hashomer, Israel

VU Medical Center; 🇳🇱 Amsterdam, Netherlands

City of Hope National Medical Center; 🇺🇸 Duarte, California, United States

Mayo Clinic Arizona; 🇺🇸 Scottsdale, Arizona, United States