Prehabilitation to Enhance Functional Capacity in Esophageal Cancer Care
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Oxygen consumption (VO2)
研究概览
简要总结
Prehabilitation utilizes the preoperative period to prevent or attenuate the treatment-related functional decline and its consequences. This project aims at testing feasibility and effectiveness of multimodal prehabilitation in esophageal cancer care.
详细描述
While evidence on prehabilitation is mounting, upper gastrointestinal surgery still remains under-investigated. This trial aims to explore the effect of prehabilitation over the whole perioperative trajectory, including neo-adjuvant treatment (NAT).
Multimodal prehabilitation includes exercise, nutrition therapy, and mental distress coping strategies. In the context of a multimodal approach, the two groups follow different exercise prescriptions: high-intensity interval supervised training prescribed accordingly cardiopulmonary exercise testing (CPET)-derived variables, versus a home-based program. For both groups, multimodal prehabilitation is prescribed over the whole preoperative period, including during NAT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with non-metastatic esophageal cancer undergoing neo-adjuvant chemotherapy and surgery.
排除标准
- •co-morbid medical, physical and mental conditions that contraindicate exercise or oral nutrition
结局指标
主要结局
Oxygen consumption (VO2)
时间窗: Change from baseline to post neo-adjuvant therapy (average duration 6-8 weeks)
Oxygen consumption at anaerobic threshold (VO2 at AT) measured with cardiopulmonary exercise testing (CPET)
次要结局
未报告次要终点
研究者
Franco Carli
Professor
McGill University Health Centre/Research Institute of the McGill University Health Centre