Prehabilitation to Enhance Functional Capacity in Esophageal Cancer Care
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Esophageal Cancer
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Oxygen consumption (VO2)
- Last Updated
- 4 years ago
Overview
Brief Summary
Prehabilitation utilizes the preoperative period to prevent or attenuate the treatment-related functional decline and its consequences. This project aims at testing feasibility and effectiveness of multimodal prehabilitation in esophageal cancer care.
Detailed Description
While evidence on prehabilitation is mounting, upper gastrointestinal surgery still remains under-investigated. This trial aims to explore the effect of prehabilitation over the whole perioperative trajectory, including neo-adjuvant treatment (NAT). Multimodal prehabilitation includes exercise, nutrition therapy, and mental distress coping strategies. In the context of a multimodal approach, the two groups follow different exercise prescriptions: high-intensity interval supervised training prescribed accordingly cardiopulmonary exercise testing (CPET)-derived variables, versus a home-based program. For both groups, multimodal prehabilitation is prescribed over the whole preoperative period, including during NAT.
Investigators
Franco Carli
Professor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Eligibility Criteria
Inclusion Criteria
- •Patients with non-metastatic esophageal cancer undergoing neo-adjuvant chemotherapy and surgery.
Exclusion Criteria
- •co-morbid medical, physical and mental conditions that contraindicate exercise or oral nutrition
Outcomes
Primary Outcomes
Oxygen consumption (VO2)
Time Frame: Change from baseline to post neo-adjuvant therapy (average duration 6-8 weeks)
Oxygen consumption at anaerobic threshold (VO2 at AT) measured with cardiopulmonary exercise testing (CPET)