Structural and functional imaging of the frontoparietal cerebral cortex in the detection of mild cognitive impairment
- Conditions
- Milde cognitieve stoornissen (geheugenpoli)Mild cognitive impairmentpreclinical dementia
- Registration Number
- NL-OMON32688
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Patients should have a least an impairment in the memory domain, with a CDR score 0.5, whereas participants in the control group should be cognitive healthy as determined by neuropsychological assessments. For both groups, the age range is between 58-68 years old. Only male patients will be included, who are right-handed or ambidexter and who have an average level of education. Participants have to fill in an informend consent and a screening questionnaire that contains questions about home adress, age, handedness, sensory functioning, profession, educational level, lifestyle, health and MRI-exclusion criteria
Participants who do not fulfill the MRI-safety criteria are not allowed in the study Furthermore, people with reduced vision, psychoactive medication use, substance abuse, past or present psychiatric or neurological disorders and structural abnormalities in the brain are not included in the study. Control participants with neuropsychological test results below average (based on normative data) will be excluded.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main outcome measures are performance (mean reaction time and accuracy) and<br /><br>the Blood Oxygen Level Dependent (BOLD) response during the functional tasks.<br /><br>Firstly, the differences in BOLD response between groups will be calculated.<br /><br>Secondly, the functional network underlying this performance will be analyzed<br /><br>by using fractional anisotropy measures and granger causality mapping.</p><br>
- Secondary Outcome Measures
Name Time Method <p>White matter lesions will be taken in consideration and resting state<br /><br>connectivity will be analyzed</p><br>