Structural and functional neural correlates of the experience of selfagency in health and schizophrenia

Completed

Conditions: delusions
psychosis
10039628

Registration Number: NL-OMON34317

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 96

Inclusion Criteria

Patients:
-Do have a DSM-IV diagnosis of schizophrenia
-Do not chronically use medication, other than psychiatric medication
-Give written informed consent
-Do not have a major medical history
-Are not in an acute psychotic episode
Healthy subjects:
-Do not have a psychiatric history
-Do not have a first-degree family member with a psychiatric illness with psychotic features.
-Do not chronically use medication
-Give written informed consent
-Do not have a major medical history;Specific for the imaging study:
Subjects have to satisfy the following criteria in order to participate in the study:
-Do not have a pacemaker
-Do not have metal materials in the head (except for dental braces)

Exclusion Criteria

All subjects:
-Drug or alcohol abuse over a period of six months prior to the experiment
-History of closed-head injury
-History of neurological illness or endocrinological dysfunction
-Unable to give consent;Specific for the imaging study:
-Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
-Claustrophobia

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Study 1:<br /><br>- Performance of patients on selfagency paradigm compared to controls (off<br /><br>line, i.e. no MRI scanner))<br /><br><br /><br>Study 2:<br /><br>- Difference between patients and controls in volume (sMRI) or density (VBM) in<br /><br>selfagency related brain areas.<br /><br>- Finding the areas in healthy controls that are involved when attributing<br /><br>selfagency to one*s own actions using the BOLD signal (fMRI)<br /><br>- Difference between patients and controls in brain activation (BOLD) while<br /><br>doing a selfagency task</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Baseline values or parameters which might intervene with the main study<br /><br>parameter (age, gender, years of education, symptoms, level of functioning,<br /><br>medication intake)</p><br>