NCT01812590已完成不适用
Acute Exercise and Pancreatic Endocrine Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Pancreatic endocrine function
研究概览
简要总结
Subjects with type 2 diabetes will be stratified into two-quantiles based on ambient hyperglycemia (fasting glucose and HbA1c) and then the effects of a single aerobic exercise bout (1-hour at 50%VO2max) on pancreatic endocrine function will be determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Previous diagnosis with type 2 diabetes, or newly detected in our screening procedures
- •Age 30-70 years
- •BMI 20-40 kg/m2
排除标准
- •Treatment with insulin
- •Contraindication to exercise as determined by ECG
- •Pregnancy
- •Active weight loss in the previous 6 months
- •Actively engaged in exercise training programs
- •Evidence of chronic pulmonary, cardiovascular, hepatic, renal, or hematological disease
结局指标
主要结局
Pancreatic endocrine function
时间窗: 24-hours following a period of rest/exercise
Insulin and glucagon secretory responses to intravenous glucose (hyperglycemic clamp 5.4 mmol/l above basal), glucagon-like peptide-1 (0.5 pmol/kg/min), and arginine (5 g injection) will be determined.
次要结局
未报告次要终点
研究者
Thomas Solomon
Senior Researcher
Rigshospitalet, Denmark
研究点 (1)
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