A Comparison of the Acute Impact of High-intensity Interval Training, Reduced-exertion High-intensity Interval Training and Moderate-intensity Continuous Aerobic Exercise on Free-living Glycaemic Control in Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Mean 24-hour blood glucose concentrations (mmol/L)
研究概览
简要总结
Exercise is considered one of the three cornerstones of type 2 diabetes (T2D) care programmes (together with diet and medication), yet the majority of individuals with T2D do not achieve the minimum recommended levels of physical activity. Two of the key barriers to exercise appear to be a 'lack of time' and the high levels of perceived exertion and fatigue. At Ulster University, it has recently been demonstrated that a modified high-intensity interval training (HIT) intervention, consisting of 10-min of low-intensity cycling interspersed with two 20-s 'all-out' sprints (reduced-exertion HIT; REHIT), was effective at improving insulin sensitivity in sedentary men over six weeks. Importantly, these benefits were observed despite the very low time commitment (just 10-min per session) and relatively low ratings of perceived exertion ('somewhat hard'). As REHIT is associated with substantial muscle glycogen breakdown, we hypothesise that this exercise mode may also acutely improve glycaemic control in patients with T2D. This study will:
- Examine the acute impact of REHIT, compared with a no-exercise control, on 24-hour glycaemic control under dietary-controlled but otherwise 'free-living' conditions using continuous glucose monitoring.
- Compare the effects of REHIT with currently recommended levels of aerobic exercise and a previously recommended HIT model, both of which have been shown to improve 24-hour glycaemic control in T2D.
- Collect information on individual's perceptions of each exercise mode through measures of affect, motivation, perceived exertion, fatigue, enjoyment and attentional focus.
详细描述
This study aims to determine the effects of a novel high-intensity interval exercise session (REHIT) on blood glucose levels over a typical 24 hour period. The effects of REHIT will be compared with another form of high intensity interval exercise that has previously been shown to be beneficial in T2D and with currently recommended moderate intensity aerobic exercise.
Participants:
21 men (aged 18-60) with type 2 diabetes will be recruited. Volunteers will be eligible to take part if they have been diagnosed with type 2 diabetes by a clinician at least 3 months prior to the study, and do not have any of the exclusion criteria for the study. Potential volunteers will be checked for reasons why the strenuous exercise may be unsuitable for them. Participants will be informed of the experimental protocol, and potential risks, both verbally and in writing before providing their written informed consent. The study will be conducted in accordance with the Declaration of Helsinki.
Pre-Screening and Baseline testing:
Before examining the effects of exercise participants will be asked to come to the lab on 5 separate occasions, which will be arranged to accommodate individual schedules:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •18-60 year-old men who have been diagnosed with Type 2 diabetes by a clinician at least 3 months prior to the start of the study according to standard criteria.
- •Able and willing to safely comply with all study procedures.
- •Able to provide written informed consent whilst acknowledging their freedom to withdraw at any point during the study.
- •Inactive or moderately physically active according to the International Physical Activity Questionnaire.
排除标准
- •Aged < 18 years or > 60 years
- •Insulin therapy
- •Use of more than two antidiabetic drugs
- •Use of βblockers
- •Use of inhaled steroids (e.g. for asthma)
- •Any cardiovascular condition with the exception of well-controlled uncomplicated hypertension (systolic >160 mmHg and/or >90mmHg after at least 5 min of seated rest), which is treated with no more than two drugs (either an ACE, ARB, calcium channel blocker, or diuretic)
- •Cerebrovascular disease including previous stroke or aneurysm
- •History of exercise-induced asthma
- •History of Type 1 diabetes mellitus or a history of ketoacidosis
- •History of other specific types of diabetes (e.g., genetic syndromes, secondary pancreatic diabetes, diabetes due to endocrinopathies, drug or chemical-induced, and post organ transplant)
- •Any prior history of malignancy with the exception of: basal cell carcinoma of the skin, squamous cell carcinoma of the skin that has been recurrence free for 5 years, other malignancies (regardless of site) that have been recurrence free for 10 years.
- •History of respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease
- •History of musculoskeletal or neurological disorders
- •Active inflammatory bowel disease
- •History of renal disease
- •Other metabolic diseases, including hyper/ hypo parathyroidism, hyper/hypo thyroidism, and Cushing's disease.
- •BMI>35 kg/m2
- •Uncontrolled hypertension (systolic blood pressure >160 mm Hg and/or diastolic blood pressure >90 mm Hg after at least a 5 minute seated rest at the screening visit).
- •A clinically significant resting and/or exercise ECG abnormality at the pre-screening visit which in the opinion of the cardiovascular physiologist exposes the participant to risk by take part in the main trial. In line with The Society for Cardiological Science & Technology recommendations for exercise testing, this includes:
- •Central nervous system symptoms (e.g. ataxia, dizziness, or near syncope)
- •Signs of poor perfusion (cyanosis or pallor)
- •Any detection of arrhythmias
- •Rapid ST elevation with or without pain
- •Systolic blood pressures >230mmHg
- •>2mm ST elevation with symptoms
- •>3mm ST depression without symptoms
- •'Yes' to any questions on a standard physical activity readiness questionnaire (PARQ)
- •Classification as highly physically active on the International Physical Activity Questionnaire (IPAQ)
- •Current participation in another research study
- •Inability to fully understand the verbal and written descriptions of the study in English, and the instructions provided during the study
结局指标
主要结局
Mean 24-hour blood glucose concentrations (mmol/L)
时间窗: 24-hours
24-hour glucose levels will be measured with continuous glucose monitors under standard dietary conditions. Mean blood glucose (mmol/L) will be calculated.
次要结局
- Time spent in hyperglycaemia (% of 24-h day)(24-hours)
- Incremental Area Under the Curve (AUC)(24 Hours)
- Glycaemic Variability (Glucose levels)(24-hours)