Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function During One-lung Ventilation

Not Applicable

Completed

• Conditions: Video-assisted Thoracic Surgery
• Interventions: Procedure: transesophageal echocardiography(TEE)

• Registration Number: NCT02365311
• Lead Sponsor: Yonsei University

Brief Summary

The investigators used transesophageal echocardiography (TEE) to assess the change of pulmonary blood flow and bi-ventricular function during lung isolation. The investigators hypothesized that changes in pulmonary venous flow with lung isolation may be related the shunt fraction and oxygenation during one lung ventilation (OLV). The investigators also observed the cardiac function during two lung ventilation (TLV) and OLV in supine and lateral position by TEE.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09
• Primary Completion: 2015-01
• Study First Submitted: 2015-02-02
• Study First Submitted QC: 2015-02-10
• Study First Posted: 2015-02-18
• Study Completion: 2015-03
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-15
• Last Update Posted: 2015-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Above 20 years of age.
• American Society of Anesthesiologists (ASA) Physical Status I and II
• Thoracic surgical procedure (video-assisted)

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Exclusion Criteria

• severe functional liver or kidney disease
• cardiac disease
• arrhythmia
• exceed BMI > 30 kg/ m2
• COPD
• pathologic esophageal lesion (esophageal stricture or varix )
• pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
one lung group	transesophageal echocardiography(TEE)	-

Primary Outcome Measures

Name	Time	Method
The change of pulmonary blood flow	two-lung ventilation in the supine (T1) and lateral position (T2) and 10 (T3), 20 (T4), and 30 min (T5) during OLV in the left lateral decubitus position.	Pulmonary blood flow = PVA(cross sectional area of LUPV) x VTI(velocity time integral) x HR , Fractional area change = \[(LVAd-LVAs)/LVAd\] × 100 Ejection fraction = \[(LVEDV(LV end-diastolic volume) -LVESV(LV end-systolic volume)/LVEDV\] × 100

Secondary Outcome Measures

Name	Time	Method
The changes of respiratory parameters	two-lung ventilation in the supine (T1) and lateral position (T2) and 10 (T3), 20 (T4), and 30 min (T5) during OLV in the left lateral decubitus position.	shunt fraction Qs/Qt = (CcO2- CaO2)/(CcO2- CvO2) CcO2 = Hgb x 1.34 x ScO2 + PcO2 x 0.003, lung compliance : Compliance= Vt / Pplat, physiologic dead space : Vd/Vt = 1.14 x (PaCO2 - PETCO2)/PaCO2- 0.005
The change of cardiac function	two-lung ventilation in the supine (T1) and lateral position (T2) and 10 (T3), 20 (T4), and 30 min (T5) during OLV in the left lateral decubitus position.

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of