Echocardiographic Assessment of Pulmonary Transit Time Following Exercise
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Heart Failure, Diastolic
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Pulmonary Transit Time
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.
Detailed Description
The ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. In some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. Currently, the amount of fluid is measured invasively. We have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. We now seek to find out if we can make a similar measurement after exercise. If successful, the need for catheter procedures may be reduced in certain types of heart failure.
Investigators
Ken Monahan
Assistant Professor of Medicine
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years old
- •Able to give informed consent
Exclusion Criteria
- •Known allergic reaction to Definity or Optison ultrasound contrast
- •Pregnancy/Nursing - as assessed/disclosed by the participant
Outcomes
Primary Outcomes
Pulmonary Transit Time
Time Frame: 3-10 seconds
interval required for the pulmonary blood volume to traverse the pulmonary circulation