Intraoperative Echocardiographic Evaluation of Pulmonary Vein Velocities and Outcomes in Lung Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Transplant Failure
- Sponsor
- Ohio State University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- incidence of graft dysfunction
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study will evaluate if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
Detailed Description
Lung transplantation surgery can be fraught with a multitude of early as well as delayed complications leading to increased morbidity and mortality. During lung transplant surgery, trans-esophageal echocardiography (TEE) is routinely used to identify cardiac anatomy and measure blood flow through the pulmonary veins. This blood flow is assessed both before and after the lung has been transplanted. Blood flow through these small caliber vessels can be impacted by many variables with a resulting reduction in blood circulating to the lung, although currently there is no agreement on an acceptable level of flow. This study will look at retrospective data from lung transplant surgeries undertaken at this institution since Jan 1st 2014 until November 18th 2016 with the goal of determining if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
Investigators
Amar Bhatt
Attending Physician
Ohio State University
Eligibility Criteria
Inclusion Criteria
- •All adult patients ≥ 18 years of age
- •Having undergone single or bilateral lung transplantation surgery at Ohio State University Wexner Medical Center between January 1st 2014 and November 18th 2016
Exclusion Criteria
- •Patients ≤ 18 years of age
Outcomes
Primary Outcomes
incidence of graft dysfunction
Time Frame: at 30 days post-transplant
To describe the relationship between intra-operative pulmonary vein systolic velocities and the incidence of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT).
grade of graft dysfunction
Time Frame: at 30 days post-transplant
To describe the relationship between intra-operative pulmonary vein systolic velocities and grade of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT).
Secondary Outcomes
- All-cause mortality(at 30 days post-transplant)
- Hospital Length of Stay(From hospital admission to discharge up to one year.)