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临床试验/NCT03052153
NCT03052153已完成不适用

Intraoperative Echocardiographic Evaluation of Pulmonary Vein Velocities and Outcomes in Lung Transplantation

Ohio State University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2017年3月17日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
incidence of graft dysfunction

研究概览

简要总结

This study will evaluate if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.

详细描述

Lung transplantation surgery can be fraught with a multitude of early as well as delayed complications leading to increased morbidity and mortality. During lung transplant surgery, trans-esophageal echocardiography (TEE) is routinely used to identify cardiac anatomy and measure blood flow through the pulmonary veins. This blood flow is assessed both before and after the lung has been transplanted. Blood flow through these small caliber vessels can be impacted by many variables with a resulting reduction in blood circulating to the lung, although currently there is no agreement on an acceptable level of flow. This study will look at retrospective data from lung transplant surgeries undertaken at this institution since Jan 1st 2014 until November 18th 2016 with the goal of determining if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All adult patients ≥ 18 years of age
  • Having undergone single or bilateral lung transplantation surgery at Ohio State University Wexner Medical Center between January 1st 2014 and November 18th 2016

排除标准

  • Patients ≤ 18 years of age

结局指标

主要结局

incidence of graft dysfunction

时间窗: at 30 days post-transplant

To describe the relationship between intra-operative pulmonary vein systolic velocities and the incidence of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT).

grade of graft dysfunction

时间窗: at 30 days post-transplant

To describe the relationship between intra-operative pulmonary vein systolic velocities and grade of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT).

次要结局

  • All-cause mortality(at 30 days post-transplant)
  • Hospital Length of Stay(From hospital admission to discharge up to one year.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Amar Bhatt

Attending Physician

Ohio State University

研究点 (1)

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