Spinal block with 0.75% Ropivacaine heavy versus 0.5% Bupivacaine heavy for short urological procedures in elderly population: A Randomized, Comparative and Controlled study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- 1.Time of onset of sensory block (minutes)
研究概览
简要总结
0.5% Bupivacaine has been widely used for spinal anaesthesia. However, it is associated with various side effects like, prolonged motor blockade, urinary retention, cardio-vascular as well as central nervous system toxicity due to its high lipid solubility. Short length of carbon chain makes ropivacaine less lipid soluble. Being less lipophilic, Ropivacaine has less cardio-toxicity and more selective sensory versus motor toxicity. With this background we are undertaking this study to verify the beneficial properties of hyperbaric ropivacaine in elderly patients posted for short urological procedures under spinal block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 50.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of age ≥50 years
- •ASA Grade-I & II
- •Undergoing short urological procedures under SAB.
排除标准
- •Patient refusal
- •ASA Grade-III & IV
- •Unstable hemodynamic status
- •Allergic to study agents
- •Any contraindication to SAB
- •Coagulopathy •Prolonged urological procedures requiring conversion to general anaesthesia or any anaesthetic supplementation •Mental disorders, such as schizophrenia and psychosis on long-term psychotropic drugs.
结局指标
主要结局
1.Time of onset of sensory block (minutes)
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
2. Maximum cephalic spread (dermatome)
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
3. Time to maximum cephalic spread (minutes)
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
8. Degree of block assessed by Bromage scale
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
4. Two segment regression time (minutes)
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
7. Total duration of sensory block (minutes)
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
9. Intra-operative vital parameters
时间窗: After the spinal block is given and during the surgical procedure at 15 minutes interval
次要结局
- 1. In recovery room pulse rate, blood pressure, respiratory rate and SPO2 will be monitored(2. Time of need of analgesia by patients)