Comparison of two drugs for spinal anaesthesia in patients of older age group undergoing short urological procedures

Not yet recruiting

• Conditions: Diseases of the genitourinary system,

• Registration Number: CTRI/2022/05/042386
• Lead Sponsor: Nidhi Arun

Brief Summary

0.5% Bupivacaine has been widely used for spinal anaesthesia. However, it is associated with various side effects like, prolonged motor blockade, urinary retention, cardio-vascular as well as central nervous system toxicity due to its high lipid solubility. Short length of carbon chain makes ropivacaine less lipid soluble. Being less lipophilic, Ropivacaine has less cardio-toxicity and more selective sensory versus motor toxicity. With this background we are undertaking this study to verify the beneficial properties of hyperbaric ropivacaine in elderly patients posted for short urological procedures under spinal block.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-05
• Last Update Posted: 2022-12-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients of age ≥50 years 2.
• ASA Grade-I & II 3.
• Undergoing short urological procedures under SAB.

Exclusion Criteria

• Patient refusal 2.
• ASA Grade-III & IV 3.
• Unstable hemodynamic status 4.
• Allergic to study agents 5.
• Any contraindication to SAB 6.
• Coagulopathy •Prolonged urological procedures requiring conversion to general anaesthesia or any anaesthetic supplementation •Mental disorders, such as schizophrenia and psychosis on long-term psychotropic drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Time of onset of sensory block (minutes)	After the spinal block is given and during the surgical procedure at 15 minutes interval
8. Degree of block assessed by Bromage scale	After the spinal block is given and during the surgical procedure at 15 minutes interval
2. Maximum cephalic spread (dermatome)	After the spinal block is given and during the surgical procedure at 15 minutes interval
3. Time to maximum cephalic spread (minutes)	After the spinal block is given and during the surgical procedure at 15 minutes interval
4. Two segment regression time (minutes)	After the spinal block is given and during the surgical procedure at 15 minutes interval
7. Total duration of sensory block (minutes)	After the spinal block is given and during the surgical procedure at 15 minutes interval
9. Intra-operative vital parameters	After the spinal block is given and during the surgical procedure at 15 minutes interval

Secondary Outcome Measures

Name	Time	Method
1. In recovery room pulse rate, blood pressure, respiratory rate and SPO2 will be monitored	2. Time of need of analgesia by patients

Trial Locations

Locations (1)

Indira Gandhi Institute of Medical Sciences; 🇮🇳 Patna, BIHAR, India

Indira Gandhi Institute of Medical Sciences

🇮🇳Patna, BIHAR, India

Nidhi Arun

Principal investigator

9523594059

janya.mukesh@yahoo.com