NL-OMON47123
Completed
Not Applicable
ong-term Outcome of Bronchopulmonary Dysplasia * Focus on Cardiovascular Health - MRI-exercise study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- cardiovascular health
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 76
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Healthy control group (n\<\=36; 16 for Part A, 20 for Part B); Young adults born a term at a gestational age \* 37 weeks, age 18\-25 years. For Part B, if possible, siblings of the participants of the preterm or BPD group are asked to participate to reduce potential lifestyle and socio\-economic confounding effects.
- •2\. Preterm group (n\<\=20, for Part B); Young adults born prematurely at a gestational age \* 30 weeks, not diagnosed with BPD in the neonatal phase, age 18\-25 years.
- •3\. BPD group (n\<\=20, for Part B); Young adults born prematurely at a gestational age \* 30 weeks, diagnosed with BPD in the neonatal phase, age 18\-25 years. BPD is defined as oxygen dependency 28 days after birth. The severity of disease depends on the need of oxygen at 36 weeks of corrected gestational age; mild BPD no supplemental oxygen at 36\-week, moderate BPD \* 30% of supplemental oxygen, and severe BPD mechanical ventilation and/or oxygen \>30 %.
Exclusion Criteria
- •\- Known acquired or congenital hemodynamically significant heart disease (except heart disease as a consequence of pulmonary hypertension)
- •\- Pulmonary disorders other than BPD
- •\- Kidney disorders
- •\- Neurodevelopmental disabilities that would prevent cooperation with CPET and/or CMR imaging.
- •\- Absence of written informed consent
Outcomes
Primary Outcomes
Not specified
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