ong-term Outcome of Bronchopulmonary Dysplasia * Focus on Cardiovascular Health - MRI-exercise study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 76 人开始时间: 待定最近更新: 2024年8月19日

适应症

试验速览

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•1. Healthy control group (n<=36; 16 for Part A, 20 for Part B); Young adults born a term at a gestational age * 37 weeks, age 18-25 years. For Part B, if possible, siblings of the participants of the preterm or BPD group are asked to participate to reduce potential lifestyle and socio-economic confounding effects.
•2. Preterm group (n<=20, for Part B); Young adults born prematurely at a gestational age * 30 weeks, not diagnosed with BPD in the neonatal phase, age 18-25 years.
•3. BPD group (n<=20, for Part B); Young adults born prematurely at a gestational age * 30 weeks, diagnosed with BPD in the neonatal phase, age 18-25 years. BPD is defined as oxygen dependency 28 days after birth. The severity of disease depends on the need of oxygen at 36 weeks of corrected gestational age; mild BPD no supplemental oxygen at 36-week, moderate BPD * 30% of supplemental oxygen, and severe BPD mechanical ventilation and/or oxygen >30 %.

•- Known acquired or congenital hemodynamically significant heart disease (except heart disease as a consequence of pulmonary hypertension)
•- Pulmonary disorders other than BPD
•- Kidney disorders
•- Neurodevelopmental disabilities that would prevent cooperation with CPET and/or CMR imaging.
•- Absence of written informed consent

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