Efficacy of aerosol therapy via high-flow nasal cannula with vibrating mesh nebulizer vs. conventional jet nebulization in stable COPD patients: A randomized cross-over trial

Phase 3

Completed

• Conditions: Patients with stable COPD; Bronchodilator; COPD; High-flow oxygen therapy; Mesh nebullizer

• Registration Number: TCTR20210317006
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-17
• Study Completion: 2021-10-31
• Results First Posted: 2024-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Age >/= 40 years old
2. Diagnosed COPD according to GOLD criteria
3. Irreversible airflow obstruction
4. Post-bronchodilator FEV1 between 35-80 %predicted

Exclusion Criteria

1. History of acute exacerbation of COPD or lower respiratory tract infection within 4 weeks
2. Contraindications for spirometry
3. Allergy to salbutamol
4. Pregnant woman
5. Deny to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Force expiratory volume at 1 second 15 minutes Spirometry

Secondary Outcome Measures

Name	Time	Method
Total lung capacity 15 minutes Body plethysmography,Airway resistance 15 minutes Impuse oscillometry