Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

Terminated

Brief Summary: RATIONALE: Collecting and studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies collecting tissue samples from patients with HIV-related malignancies.

Detailed Description: OBJECTIVES:

* To obtain high-quality, clinically annotated tissue from patients with human immunodeficiency virus (HIV)-1 malignancy.

* To study clinical, genetic, and immunologic parameters that have prognostic significance and/or are involved in the initiation and progression of HIV-1 malignancies, including complete genomic sequence determination of HIV-associated diffuse large B-cell lymphomas, lung cancer, anal cancer, and cervical cancer.

OUTLINE: This is a multicenter study.

Patients undergo tumor, lymph node, bone marrow, or skin biopsy, and peripheral blood mononuclear cells collection. Samples are submitted to the AIDS Malignancy Consortium (AMC) Biorepository and transferred to the AIDS and Cancer Specimen Resource (ACSR). Samples are then analyzed by the Genome Science Center of British Columbia (GSC-BC) and the HIV+ Tumor Molecular Characterization Project (HTMCP) for full genomic sequencing analysis that may include, but are not limited to, array-based gene expression profiling, comparative genome hybridization, and single nucleotide polymorphism studies by flow cytometry, cytogenetics, and molecular studies. Patients' clinical data, demographics, and treatment given are also collected prospectively in order to record treatment outcome and toxicity.

Patients are followed up at 6 months, 1 year, and 2 years for data-reporting purposes.

Recruitment & Eligibility

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Primary Outcome Measures

Name	Time	Method
Collection of Tissue Specimen From Study Participants	Study entry (prior to chemotherapy initiation)	Summary of the specimens available by study arm

Secondary Outcome Measures

Name	Time	Method

Locations (14): Moores UCSD Cancer Center
🇺🇸
La Jolla, California, United States
UCLA Clinical AIDS Research and Education (CARE) Center
🇺🇸
Los Angeles, California, United States
George Washington University
🇺🇸
Washington, District of Columbia, United States
University of Miami
🇺🇸
Miami, Florida, United States
John H. Stroger Hospital of Cook County
🇺🇸
Chicago, Illinois, United States
Louisiana State University Public Hospital
🇺🇸
New Orleans, Louisiana, United States
Washington University School of Medicine
🇺🇸
Saint Louis, Missouri, United States
Albert Einstein Cancer Center at Albert Einstein College of Medicine
🇺🇸
Bronx, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸
New York, New York, United States
UNC Lineberger Comprehensive Cancer Center
🇺🇸
Chapel Hill, North Carolina, United States
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Moores UCSD Cancer Center
🇺🇸La Jolla, California, United States