Risk Markers of Arterial Aging and Subsequent Risk of Cardiovascular Diseases and Beyond. The Paris Prospective Study III-2
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 7,500
- Locations
- 2
- Primary Endpoint
- carotid diameter
Study Overview
Brief Summary
The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.
Detailed Description
Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 60 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Being enrolled in PPS3 and having signed an informed consent for PPS3-2
Exclusion Criteria
- •Institutionalized participants
- •Participants under guardianship
- •Participants under judicial safeguard measure
Arms & Interventions
Level of vascular aging
community-based prospective longitudinal cohort
Intervention: high-precision carotid echo-tracking (Other)
Outcomes
Primary Outcomes
carotid diameter
Time Frame: by 2027
high precision carotid echo tracking diameter in mm
intima media thickness
Time Frame: by 2027
high precision echo tracking intima media thickness of the common carotid artery in mm
carotid plaques
Time Frame: by 2027
high precision carotid echo tracking carotid plaques
elastic modulus
Time Frame: by 2027
high precision carotid echo tracking Young's elastic modulus, 10-3\*kPa
pulse wave velocity
Time Frame: by 2027
high precision carotid echotracking pulse wave velocity, m/s
carotid wall stress
Time Frame: by 2027
high precision carotid echotracking circumferential wall stress in kPa
wall cross sectional area
Time Frame: by 2027
high precision carotid echo tracking carotid wall cross sectional area, mm2
pulse pressure
Time Frame: by 2027
high precision carotid echotracking pulse pressure in mmHg
distensibility coefficient
Time Frame: by 2027
high precision carotid echo tracking distensibility coefficient in 10-3/kPa
stiffness
Time Frame: by 2027
high precision carotid echotracking Beta stiffness index
Secondary Outcomes
- wall cross sectional area of the radial artery(by 2027)
- brachial artery diameter(by 2027)
- thickness of the intima media of the radial artery(by 2027)
- distensibility of the radial artery(by 2027)
- wall stress of the radial artery(by 2027)
- arterial plaques(by 2027)
- elastic modulus of the radial artery(by 2027)
- pulse wave velocity of the radial artery(by 2027)
- stiffness index of the radial artery(by 2027)
- pulse pressure of the radial artery(by 2027)