Study on the application and mechanism of synchronous percutaneous electrical stimulation of zusanli by stimulating GABABR to inhibit transient lower esophageal sphincter relaxation

The Third Affiliated Hospital of Zhejiang Chinese Medical University0 个研究点开始时间: 待定最近更新: 2023年2月20日

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•The main inclusion criteria are adult patients aged 18-65 with typical symptoms such as heartburn or/and reflux lasting for >= 6 months, including:
•1. The first-treated GERD patients had not taken any drugs before enrollment;
•2. Patients with GERD who have effective PPI but need long-term maintenance;
•3. Refractory GERD patients, i.e., those who take PPI drugs regularly for 8-12 weeks, are still suffering from symptoms twice a day.

•1. Patients with scleroderma, diabetes or autonomic dysfunction;
•2. Those patients with Barrett's esophageal syndrome, esophageal intraepithelial neoplasia or esophageal cancer, esophageal polyp, esophageal varices or ulcers of any grade, previous history of esophageal or gastric surgery, esophageal hiatal hernia >= 3cm;
•3. Patients with serious complications (such as gastrointestinal bleeding, cardiopulmonary disease, serious hepatorenal disease, hematopoietic system disease, etc.);
•4. Patients with nasopharynx obstruction;
•5. Pregnant women, lactating women or women with pregnancy intention;
•6. Patients familiar with acupuncture, acupoint or meridian treatment;
•7. Patients who use antidepressants, ß - receptor antagonists, calcium antagonists, nitroglycerin and other drugs that affect esophageal motility at the same time;
•8. With claustrophobia and other mental diseases;
•9. Patients with previous implantation of metal materials.

发起方

The Third Affiliated Hospital of Zhejiang Chinese Medical University