Effects of vitamin C and grape-seed polyphenols on blood pressure in treated hypertensive individuals

Not Applicable

Completed

• Conditions: Hypertension; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular - Hypertension

• Registration Number: ACTRN12613000514707
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-05-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

All individuals were taking one or more antihypertensive drugs for 3 months, had a mean 24-h ambulatory systolic BP of 125 mmHg and at least one additional cardiovascular disease (CVD) risk factor. Risk factors included previous coronary or cerebrovascular event > 6 months, hyperlipidaemia (total cholesterol > 6 mmol/l), use of lipid-lowering therapy, or smoking > 5 cigarettes/day. All volunteers ceased any vitamin, fish oil or antioxidant supplements for at least 3 weeks prior to study entry. All usual medication was taken as prescribed on the morning of each visit and maintained for the duration of the trial.

Exclusion Criteria

Exclusion criteria included: previous coronary or cerebrovascular event 6 months, heart failure or unstable disease, premenopausal, use of nitrate medication, use of oral contraceptive, body mass index > 35 kg/m2, diabetes mellitus, fasting glucose 7 mmol/l, or elevated serum creatinine (men > 110 mmol/l or women > 100 mmol/l). Individuals were asked to limit tea and coffee intake to 3 cups/day, and cease all red wine and commercial fruit juice for the duration of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified