Optimizing Cardiac Resynchronization

University of Wisconsin, Madison1 site in 1 country100 target enrollmentJune 2004

ConditionsHeart Failure

Overview

Phase: N/A
Intervention: Not specified
Conditions: Heart Failure
Sponsor: University of Wisconsin, Madison
Enrollment: 100
Locations: 1
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Cardiac resynchronization therapy shows great promise as a method to improve ventricular function in heart failure due to dilated cardiomyopathy. It is applied to patients with class III and IV symptomatic heart failure on optimal therapy. Typical entry criteria in the trials testing resynchronization have used the electrocardiogram and a prolonged electrocardiogram (ECG) QRS interval as criteria for dyssynchrony. This is recognized to be quite limited as a tool for identifying patients. Several new echocardiographic methods for identifying dyssynchrony have been proposed. The purpose of this study is to systematically examine these multiple echocardiographic measurement techniques in three conditions:

in the patient's native rhythm simulated by changing the pacing system to atrial pacing only;
in conventional dual chamber pacing (DDD mode); and
during biventricular pacing. All patients entered into this study will already have had a biventricular pacemaker placed.

Registry

clinicaltrials.gov

Start Date

June 2004

End Date

December 2011

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Wisconsin, Madison

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•All patients who have previously had a resynchronization pacemaker system placed at the University of Wisconsin Hospital or at the Middleton Veterans Hospital are potentially eligible for this study.
•The study is only open to patients as enumerated above, and also patients who have good imaging windows.