Omzetting naar Envarsus om de ideale tijdpunten voor monitoring te vinde
- Conditions
- Envarsus, pharmocokinetic model, tacrolimus, liver transplantation, levertransplantatie
- Registration Number
- NL-OMON25477
- Lead Sponsor
- MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 55
Inclusion Criteria
Liver transplant patients at least 6 months after transplantation
Between 18 and 70 years old
Exclusion Criteria
Infections or complications at inclusion
Bilirubin and albumin level outside clinical reference range
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Population pharmokinetic parameters tacrolimus (Envarsus)<br /><br>PK dependency on CYP3A5*3, CYP3A4*22 and IL polymorphisms
- Secondary Outcome Measures
Name Time Method imited PK sampling<br /><br>Through concentration - AUC correlation<br /><br>Changes in quality of life before and after conversion