Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women

Not Applicable

Recruiting

• Conditions: Motor Activity; Postmenopausal; Menorrhagia; Physical Inactivity
• Interventions: Dietary Supplement: Beetroot juice rich in nitrate; Other: Beetroot juice NO3 depleted

• Registration Number: NCT05820321
• Lead Sponsor: University of Sao Paulo

Brief Summary

Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in which will ingest beet juice with or without NO3 in its composition with a 8-day washout interval.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-01
• Study First Submitted: 2023-01-27
• Study First Submitted QC: 2023-04-18
• Study First Posted: 2023-04-19
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-10
• Last Update Posted: 2023-06-13
• Primary Completion: 2023-08-20
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• 50 to 65 years old
• Physically inactive
• Postmenopausal diagnosis (amenorrhea for 12 months or more);

Exclusion Criteria

• Smoking
• Cardiac failure
• Previous history of acute myocardial infarction and/or stroke;
• Allergy or intolerance to nitrate, gluten, or milk;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Experimental (Beetroot juice NO3)	Beetroot juice rich in nitrate	8-day supplementation with beetroot juice rich in NO3 (400mg) during 8 days.
Placebo (Beetroot juice without NO3)	Beetroot juice NO3 depleted	8-day supplementation with beetroot juice NO3 depleted during 8 days.

Primary Outcome Measures

Name	Time	Method
Handgrip strength test (kgf)	up to 2 years

Secondary Outcome Measures

Name	Time	Method
Sit-to-stand test (repetitions)	up to 2 years
Arm curl test (repetitions)	up to 2 years
8-foot up and go test (seconds)	up to 2 years
Six minute walk test (distance in meters)	up to 2 years

Trial Locations

Locations (2)

EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo; 🇧🇷 Ribeirão Preto, São Paulo, Brazil

Cicero Jonas Rodrigues Benjamim; 🇧🇷 Ribeirao Preto, SP, Brazil