Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders

Not Applicable

Completed

• Conditions: Steroid Abuse; Cardiovascular Abnormalities

• Registration Number: NCT05835401
• Lead Sponsor: University of Sao Paulo

Brief Summary

Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-17
• Study First Submitted: 2023-04-18
• Study First Submitted QC: 2023-04-18
• Study First Posted: 2023-04-28
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-23
• Last Update Posted: 2025-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

• Anabolic steroid use in the past or actually;
• Participation at least one bodybuilding competition;

Exclusion Criteria

• Previous history of acute myocardial infarction and/or stroke;
• Allergy or intolerance to nitrate, gluten, or milk;
• Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
1. Values of systolic and diastolic blood pressure (mmHg)	up to 2 years

Secondary Outcome Measures

Name	Time	Method
Plasmatic concentrations of nitrate and nitrite (mmol/L)	up to 2 years
Values of heart rate variability (ms)	up to 2 years
Values of heart rate (beats per minute)	up to 2 years
Macrovascular function (Flow mediated dilatation%)	up to 2 years
Values of hand grip strength (kgF)	up to 2 years

Trial Locations

Locations (1)

EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo; 🇧🇷 Ribeirão Preto, São Paulo, Brazil