Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders

Not Applicable

Recruiting

• Conditions: Steroid Abuse; Cardiovascular Abnormalities
• Interventions: Dietary Supplement: Beetroot juice depleted in nitrate; Dietary Supplement: Beetroot juice rich in nitrate

• Registration Number: NCT05835401
• Lead Sponsor: University of Sao Paulo

Brief Summary

Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-04
• Study Start: 2023-04-17
• Study First Submitted: 2023-04-18
• Study First Submitted QC: 2023-04-18
• Last Update Submitted: 2023-04-18
• Study First Posted: 2023-04-28
• Last Update Posted: 2023-04-28
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Anabolic steroid use in the past or actually;
• Participation at least one bodybuilding competition;

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Exclusion Criteria

• Previous history of acute myocardial infarction and/or stroke;
• Allergy or intolerance to nitrate, gluten, or milk;
• Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo (Beetroot juice without NO3)	Beetroot juice depleted in nitrate	Acute ingestion of beetroot juice rich depleted in NO3.
Experimental (Beetroot juice NO3)	Beetroot juice rich in nitrate	Acute ingestion of beetroot juice rich in NO3 (800mg).

Primary Outcome Measures

Name	Time	Method
Macrovascular function (Flow mediated dilatation%)	up to 2 years

Secondary Outcome Measures

Name	Time	Method
Values of hand grip strength (kgF)	up to 2 years
Values of heart rate (beats per minute)	up to 2 years
Values of heart rate variability (ms)	up to 2 years
Plasmatic concentrations of nitrate and nitrite (mmol/L)	up to 2 years
Values of systolic and diastolic blood pressure (mmHg)	up to 2 years

Trial Locations

Locations (1)

EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo; 🇧🇷 Ribeirão Preto, São Paulo, Brazil