Profiling the Endocannabinoid Response to Hedonic Eating

Not Applicable

Completed

• Conditions: Food Preferences; Obesity
• Interventions: Other: Food palatability

• Registration Number: NCT03113474
• Lead Sponsor: Wageningen University

Brief Summary

Study into the endocannabinoid response to consuming a palatable versus a neutral food.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-15
• Primary Completion: 2015-10-08
• Study Completion: 2015-10-08
• Study First Submitted: 2017-04-09
• Study First Submitted QC: 2017-04-09
• Study First Posted: 2017-04-13
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-22
• Last Update Posted: 2017-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• Healthy (self-report)
• Dutch
• Evaluating one of the used foods as palatable
• Evaluating one of the used foods as neutral
• Hb value between 8.1 and 11.0 mmol/L at screening

Exclusion Criteria

• restraint eating
• lack of appetite
• difficulties eating/swallowing
• endocrine disorders
• energy restricted diet two months prior to study
• weight change > 5 kg in two months prior to study
• stomach or bowel disease
• taste or smell disorders (self-report)
• not consuming foods used in the study
• smoking > 1 cigarette per day
• drinking > 21 units alcohol per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Palatable-neutral	Food palatability	Participants are exposed to palatable food in the first test session, and to the neutral food in the second test session.
Neutral-palatable	Food palatability	Participants are exposed to neutral food in the first test session, and to the palatable food in the second test session.

Primary Outcome Measures

Name	Time	Method
Endocannainoid levels	prior to, during and two hours after eating	To assess changes in endocannabinoid plasma levels prior to, during and after eating a palatable versus a neutral food

Secondary Outcome Measures

Name	Time	Method
Pancreatic polypeptide (pg/ml)	prior to, during and two hours after eating	To assess changes in pancreatic polypeptide plasma levels prior to, during and after eating a palatable versus a neutral food
Ghrelin (pg/ml)	prior to, during and two hours after eating	To assess changes in ghrelin plasma levels prior to, during and after eating a palatable versus a neutral food