Profiling the Endocannabinoid Response to Hedonic Eating

Not Applicable

Completed

• Conditions: Food Preferences; Obesity

• Registration Number: NCT03113474
• Lead Sponsor: Wageningen University

Brief Summary

Study into the endocannabinoid response to consuming a palatable versus a neutral food.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-15
• Primary Completion: 2015-10-08
• Study Completion: 2015-10-08
• Study First Submitted: 2017-04-09
• Study First Submitted QC: 2017-04-09
• Study First Posted: 2017-04-13
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-22
• Last Update Posted: 2017-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• Healthy (self-report)
• Dutch
• Evaluating one of the used foods as palatable
• Evaluating one of the used foods as neutral
• Hb value between 8.1 and 11.0 mmol/L at screening

Exclusion Criteria

• restraint eating
• lack of appetite
• difficulties eating/swallowing
• endocrine disorders
• energy restricted diet two months prior to study
• weight change > 5 kg in two months prior to study
• stomach or bowel disease
• taste or smell disorders (self-report)
• not consuming foods used in the study
• smoking > 1 cigarette per day
• drinking > 21 units alcohol per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Endocannainoid levels	prior to, during and two hours after eating	To assess changes in endocannabinoid plasma levels prior to, during and after eating a palatable versus a neutral food

Secondary Outcome Measures

Name	Time	Method
Pancreatic polypeptide (pg/ml)	prior to, during and two hours after eating	To assess changes in pancreatic polypeptide plasma levels prior to, during and after eating a palatable versus a neutral food
Ghrelin (pg/ml)	prior to, during and two hours after eating	To assess changes in ghrelin plasma levels prior to, during and after eating a palatable versus a neutral food