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Clinical Trials/NCT02310360
NCT02310360
Active, not recruiting
Not Applicable

Measuring Food-induced Striatal and Extra-striatal Dopamine Release Using (18F)Fallypride Positron Emission Tomography

Universitaire Ziekenhuizen KU Leuven1 site in 1 country12 target enrollmentNovember 2014
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ConditionsAppetite Regulation

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Appetite Regulation
Sponsor
Universitaire Ziekenhuizen KU Leuven
Enrollment
12
Locations
1
Primary Endpoint
DA release in both striatal and extra-striatal brain regions
Status
Active, not recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The purpose of this study is to investigate whether a combination of taste probes and food-related cues can induce dopamine release in striatal and extra-striatal brain regions in healthy subjects.

Registry
clinicaltrials.gov
Start Date
November 2014
End Date
March 2025
Last Updated
last year
Study Type
Observational
Sex
Female

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •20 ≤ BMI ≤ 25
  • •Right handed
  • •Stable body weight for at least 3 consecutive months at start of study and no history of behavioral, therapeutic or surgical treatment aiming at or leading to weight loss/gain
  • •Subject understands the study procedures and agrees to participate in the study by giving written informed consent

Exclusion Criteria

  • •Medical (current or history):
  • •Abdominal/thoracic surgery except appendectomy
  • •Gastrointestinal, endocrine (especially diabetes), or neurological diseases
  • •Cardiovascular, respiratory, renal or urinary diseases
  • •Hypertension
  • •Food or drug allergies
  • •Head trauma with loss of consciousness
  • •Psychiatric disorders (current or history):
  • •Eating disorders
  • •Psychotic disorders

Outcomes

Primary Outcomes

DA release in both striatal and extra-striatal brain regions

Time Frame: 1 year

A \[18F\]Fallypride PET protocol and the linearized simplified reference region model (LSSRM) kinetic model will be used to detect DA release.

Study Sites (1)

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