Sensory Study: Taste and Tongue Biology
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Adults
- Sponsor
- University of Massachusetts, Amherst
- Enrollment
- 121
- Locations
- 1
- Primary Endpoint
- Gene expression and sweet taste perception
- Status
- Completed
- Last Updated
- 9 months ago
Overview
Brief Summary
Researchers will investigate the correlation between a) self-reported dietary intake of foods and beverages, b) intensity of sucrose stimuli, and c) liking rating of sweet stimuli, with the relative expression of the taste receptor genes from human fungiform papillae (TAS1R2 and TAS1R3).
* This research will provide new information on how sweet taste perception is regulated.
- The hypothesis: Greater dietary consumption of sugar and sweet foods is associated with reduced expression of the sweet taste receptors.
- The results of this study could help to identify pathways to help modify sweet taste perception by uncovering this mechanism.
Participants will sample solutions prepared with sweet ingredients, provide salivary DNA, and collect fungiform papillae. This will allow researchers and investigators to compare the relationship between the sweetness of stimuli, genetic differences in sweet taste receptors, and expression levels of sweet taste receptor genes.
Investigators
Eligibility Criteria
Inclusion Criteria
- •between 18 and 45 years old,
- •have no tongue or cheek piercings,
- •not a user of tobacco products or electronic cigarettes (within the last year),
- •no known defects in taste or smell,
- •not pregnant or breastfeeding,
- •no history of chronic pain in the mouth,
- •not taking any prescription pain medication,
- •not taking any blood thinners,
- •no history of cancer or cancer treatment,
- •not diabetic or restricting intake of sugars for medical reasons, under the direction of a physician or healthcare provider
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Gene expression and sweet taste perception
Time Frame: Day 1 (single time-point)
The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (gLMS ratings of sampled sucrose)
Gene expression and sweet taste liking
Time Frame: Day 1 (single time-point)
The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (hedonic ratings of sampled sucrose)
Gene expression and dietary intake
Time Frame: Day 1 (single time-point)
The relative gene level expression of sweet taste receptors and relationship with self-reported dietary intake of sweet foods and beverages
Gene expression and sweet liker status
Time Frame: Day 1 (single time-point)
The relative gene level expression of sweet taste receptors and relationship with the self-reported liking of a variety of sweet foods and beverages
Secondary Outcomes
- Genetics and sweet liker status(Day 1 (single time-point))
- Genetics and sweet taste perception(Day 1 (single time-point))
- Genetics and sweet taste liking(Day 1 (single time-point))