Effects of Quinoa Consumption on Markers of Cardiovascular Risk and Gastrointestinal Health
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- plasma LDL-cholesterol
研究概览
简要总结
Quinoa is possible alternative to wheat, corn and rice due to its high nutritional value and possible properties against cardiovascular diseases and for improving gut health. There are some animal studies to suggest that some important class of compounds like fibre, antioxidants and protein, found naturally in quinoa, have beneficial effects against markers of cardiovascular diseases. However, the effects of quinoa on humans has rarely been investigated. This study will investigate the effects of daily consumption of quinoa for four weeks on markers of cardiovascular risk, including blood cholesterol and resting blood pressure, and on gut health in a randomised cross-over study design.
详细描述
Quinoa is a possible alternative to wheat, corn and rice due to its high nutritional value and possible properties against cardiovascular diseases. There are some animal studies which suggest that quinoa has beneficial effects against markers of cardiovascular diseases, particularly blood lipid profile. The grain has a unique nutritional profile, with high fibre levels and a wide range of phytochemicals which may influence gut bacteria and improve gastrointestinal health.
However, the effects of quinoa on humans has rarely been investigated with just two small interventions published. These studies also showed an improvement in blood lipid profile after consuming quinoa daily. There have been no studies which have investigated the effects of quinoa on gut bacteria and gastrointestinal health. Therefore, this human dietary intervention study aims to determine the effects of quinoa consumption on markers of cardiovascular diseases, the gut microbiome and gastrointestinal health.
The study is a randomized cross-over designed dietary intervention study with 4-week study periods separated by a 4-week wash-out period. The treatment will be the daily consumption of a test bread roll containing quinoa to deliver 20g quinoa per day (one roll per day). The control will be the same amount of a refined wheat roll. Markers of cardiovascular disease risk, including fasting blood lipid profile, plasma glucose and insulin concentration, resting blood pressure will be compared at the beginning and end of each treatment period. Changes in the numbers and species of gut bacteria, and products of bacterial fermentation will be made in stool samples collected at the beginning and end of each intervention period as indicators of gastrointestinal health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men >35 years old
- •body mass index >25 kg/m2
- •Non-smokers with no known previous history of cardiovascular disease or type 2 diabetes
- •Not receiving any current medication. Supplement users will be included but will be asked to stop taking supplements for the duration of the study
排除标准
- •Age ≤ 35 or BMI ≤25
- •Individuals with known or suspected allergy to wheat
- •Individuals with known history of cardiovascular diseases or type 2 diabetes
- •Individuals with recent weight loss (>10%) or planning to lose weight during the study
结局指标
主要结局
plasma LDL-cholesterol
时间窗: Change from post dose after 4 weeks of intervention
次要结局
- Body fat(Change from post dose after 4 weeks of intervention)
- Fasting Blood glucose and insulin(Change from post dose after 4 weeks of intervention)
- BMI(Change from post dose after 4 weeks of intervention)
- Stool Microbiome profile(Change from post dose after 4 weeks of intervention)
- Blood pressure(Change from post dose after 4 weeks of intervention)
- short chain fatty acid profile of stool samples(Change from post dose after 4 weeks of intervention)
- Fasting blood lipid profile(Change from post dose after 4 weeks of intervention)