Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia
- Conditions
- Lung Cancer
- Interventions
- Registration Number
- NCT02324283
- Lead Sponsor
- Juntendo University
- Brief Summary
Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?
- Detailed Description
The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.
Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Patients agree to participate in the study
- Patients undergoing lung cancer surgery requiring one-lung ventilation.
- American Society of Anesthesiologists Physical Status Class 1 or 2
- Patients with any of the following will be excluded from lung cancer patients.
- New York Heart Association Classification more than 2
- Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
- Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
- Coagulation dysfunction
- The administration of steroids and immunosuppressive agents within 3 months prior to surgery
- Infection with active inflammation
- Pneumonectomy patients
- Cases of epidural anesthesia is contraindicated
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Propofol propofol Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1\~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured. Desflurane desflurane Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1\~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.
- Primary Outcome Measures
Name Time Method Oxygenation prior to surgery to one-hour after extubation Arterial blood gases are monitored.Pulmonary blood flow is measured using transesophageal echocardiogram.
- Secondary Outcome Measures
Name Time Method Quality of Consiousness after extubation quality of consciousness will be assessed using Aldrete score
Postoperative Nausea and Vomiting on the postoperative day 1 degree of nausea and frequency of vomiting
Rapidity of Emergence From Anesthesia one minute after cessation of anethetic agents to one hour after extubation Time to extubation and orientation, where the patient is.
Trial Locations
- Locations (1)
University of Juntendo
🇯🇵Bunkyo-ku, Tokyko, Japan